MNPs–PhSO3H: A Sustainable, Recyclable and Eco-Friendly Catalyst Promoting the Green Synthesis of 3-Aminoisoxazolmethylnaphthols Under Solvent–Free Conditions

In this article, a one-pot three-component synthesis of 3-aminoisoxazolmethylnaphthol derivatives has been developed using Fe 3 O 4 –NHPhSO 3 H as a recyclable heterogeneous nanocatalyst using available 3-aminoisoazoles, aldehyde derivatives and 2-naphthol under solvent-free conditions. This environmentally friendly methodology with excellent green chemistry credentials, such as using the low loading of reusable, nontoxic, easy- to-handle catalyst, shorter reaction time without any byproduct, avoidance of hazardous organic solvents and easy workup (the catalyst can be easily separated from the reaction mixture by an external magnet), can be used in a wide range of applications. Graphic Abstract A one-pot three-component synthesis of 3-aminoisoxazolmethylnaphthol derivatives has been developed via Fe 3 O 4 –NHPhSO 3 H as a recyclable heterogeneous nanocatalyst by available 3-aminoisoazoles, aldehyde derivatives and 2-naphthol in solvent-free conditions. This green process with main aspects such as operational simplicity, good-to-excellent yields, low cost, easy handling, being eco-friendly and reusability of the catalyst, absence of any tedious workup or purification and avoidance of hazardous or toxic reagents/catalysts/solvents opens an effective and convenient way to naphthalen-2-ol-functionalized isoxazole systems, which are promising compounds for different biomedical applications.