Synthesis and Evaluation of Antibacterial Activity of 1,2,4-Oxadiazole-Containing Biphenylcarboxylic Acids

Synthesis and Evaluation of Antibacterial Activity of 1,2,4-Oxadiazole-Containing Biphenylcarboxylic Acids

A one-pot method for the synthesis of biphenylcarboxylic acids containing 1,2,4-oxadiazole ring in the NaOH–DMSO system was developed. The results of in vitro experiments showed that the synthesized compounds exhibit antibacterial activity against susceptible strains of E. coli and S. aureus .

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Veröffentlicht in:Russian journal of general chemistry 2020-09, Vol.90 (9), p.1611-1619
Hauptverfasser: Tarasenko, M. V., Presnukhina, S. I., Baikov, S. V., Shetnev, A. A.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Antibacterial agents
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
E coli
Escherichia coli
Oxadiazoles
Synthesis
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Beschreibung
Zusammenfassung:A one-pot method for the synthesis of biphenylcarboxylic acids containing 1,2,4-oxadiazole ring in the NaOH–DMSO system was developed. The results of in vitro experiments showed that the synthesized compounds exhibit antibacterial activity against susceptible strains of E. coli and S. aureus .
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363220090042