Electroanalytical investigation and determination of hepatitis C antiviral drug ledipasvir at a non-modified boron-doped diamond electrode

This study is about the use of the boron-doped diamond electrode pretreated electrochemically (anodic and subsequent cathodic) in the voltammetric determination of hepatitis C antiviral drug ledipasvir. Cyclic voltammetric measurements revealed that the compound yielded two well-separated irreversib...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Diamond and related materials 2020-10, Vol.108, p.107962, Article 107962
Hauptverfasser: Allahverdiyeva, Shabnam, Keskin, Ertuğrul, Pınar, Pınar Talay, Yunusoğlu, Oruç, Yardım, Yavuz, Şentürk, Zühre
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This study is about the use of the boron-doped diamond electrode pretreated electrochemically (anodic and subsequent cathodic) in the voltammetric determination of hepatitis C antiviral drug ledipasvir. Cyclic voltammetric measurements revealed that the compound yielded two well-separated irreversible oxidation peaks (PA1 and PA2) in acidic medium. The dependence of intensities of currents and potentials on electrode pretreatment, pH and nature of the supporting electrolyte, and other variables was investigated by square-wave voltammetry. Determination of ledipasvir was performed in Britton-Robinson buffer (pH 2.0) on the basis of both PA1 and PA2, which offered linear concentration ranges 0.5–60.0 μg mL−1 (5.6 × 10−7–6.8 × 10−5 mol L−1) and 5.0–60.0 μg mL−1 (5.6 × 10−6–6.8 × 10−5 mol L−1), respectively, with detection limits of 0.12 μg mL−1 (1.4 × 10−7 mol L−1) and 0.76 μg mL−1 (8.6 × 10−7 mol L−1). The practical applicability of developed methodology was tested by the assay of a fixed-dose combination tablet with sofosbuvir. [Display omitted] •The first report on the voltammetric determination of ledipasvir on non-modified electrode•The electrode process that is irreversible and diffusion-controlled on BDD electrode•Practical applicability in a fixed-dose combination tablet form with sofosbuvir
ISSN:0925-9635
1879-0062
DOI:10.1016/j.diamond.2020.107962