Biomaterials: Dual‐Targeting Photosensitizer‐Peptide Amphiphile Conjugate for Enzyme‐Triggered Drug Delivery and Synergistic Chemo‐Photodynamic Tumor Therapy (Adv. Mater. Interfaces 19/2020)
In article number 2000935, Yin‐Jia Cheng, Xian‐Zheng Zhang and co‐workers successfully prepared a photosensitizer‐peptide amphiphile conjugate, which displays specific cellular uptake by tumor cells, and directly delivers doxorubicin to nucleus and protoporphyrin IX to mitochondria. The nanosystem c...
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| Veröffentlicht in: | Advanced materials interfaces 2020-10, Vol.7 (19), p.n/a |
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| container_title | Advanced materials interfaces |
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| creator | Cheng, Yin‐Jia Qin, Si‐Yong Liu, Wen‐Long Ma, Yi‐Han Chen, Xiao‐Sui Zhang, Ai‐Qing Zhang, Xian‐Zheng |
| description | In article number 2000935, Yin‐Jia Cheng, Xian‐Zheng Zhang and co‐workers successfully prepared a photosensitizer‐peptide amphiphile conjugate, which displays specific cellular uptake by tumor cells, and directly delivers doxorubicin to nucleus and protoporphyrin IX to mitochondria. The nanosystem can significantly maximize the therapeutic effect against tumor cells with minimal off‐target cytotoxicity, thus holding great potential for enhanced chemo‐photodynamic tumor therapy. |
| doi_str_mv | 10.1002/admi.202070108 |
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| subjects | Biocompatibility biomaterials Biomedical materials Conjugates Doxorubicin Drug delivery systems drug release enzyme‐responsive micelles Mitochondria Nuclei (cytology) Peptides Toxicity tumor therapy Tumors |
| title | Biomaterials: Dual‐Targeting Photosensitizer‐Peptide Amphiphile Conjugate for Enzyme‐Triggered Drug Delivery and Synergistic Chemo‐Photodynamic Tumor Therapy (Adv. Mater. Interfaces 19/2020) |
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