Biomaterials: Dual‐Targeting Photosensitizer‐Peptide Amphiphile Conjugate for Enzyme‐Triggered Drug Delivery and Synergistic Chemo‐Photodynamic Tumor Therapy (Adv. Mater. Interfaces 19/2020)

Biomaterials: Dual‐Targeting Photosensitizer‐Peptide Amphiphile Conjugate for Enzyme‐Triggered Drug Delivery and Synergistic Chemo‐Photodynamic Tumor Therapy (Adv. Mater. Interfaces 19/2020)

In article number 2000935, Yin‐Jia Cheng, Xian‐Zheng Zhang and co‐workers successfully prepared a photosensitizer‐peptide amphiphile conjugate, which displays specific cellular uptake by tumor cells, and directly delivers doxorubicin to nucleus and protoporphyrin IX to mitochondria. The nanosystem c...

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Veröffentlicht in:Advanced materials interfaces 2020-10, Vol.7 (19), p.n/a
Hauptverfasser: Cheng, Yin‐Jia, Qin, Si‐Yong, Liu, Wen‐Long, Ma, Yi‐Han, Chen, Xiao‐Sui, Zhang, Ai‐Qing, Zhang, Xian‐Zheng
Format: Artikel
Sprache:eng
Schlagworte:
Biocompatibility
biomaterials
Biomedical materials
Conjugates
Doxorubicin
Drug delivery systems
drug release
enzyme‐responsive
micelles
Mitochondria
Nuclei (cytology)
Peptides
Toxicity
tumor therapy
Tumors
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Zusammenfassung:In article number 2000935, Yin‐Jia Cheng, Xian‐Zheng Zhang and co‐workers successfully prepared a photosensitizer‐peptide amphiphile conjugate, which displays specific cellular uptake by tumor cells, and directly delivers doxorubicin to nucleus and protoporphyrin IX to mitochondria. The nanosystem can significantly maximize the therapeutic effect against tumor cells with minimal off‐target cytotoxicity, thus holding great potential for enhanced chemo‐photodynamic tumor therapy.
ISSN:2196-7350
2196-7350
DOI:10.1002/admi.202070108