In vitro evaluation of the hepatic lipid accumulation of bisphenol analogs: A high-content screening assay

Bisphenol A (BPA) has a variety of adverse effects on human health; therefore, BPA analogs are increasingly used as replacements. Notably, recent studies have revealed that BPA exposure induced hepatic lipid accumulation, but few studies are available regarding the similar effects of other bisphenol...

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Veröffentlicht in:	Toxicology in vitro 2020-10, Vol.68, p.104959, Article 104959
Hauptverfasser:	Liu, Qian, Shao, Wentao, Weng, Zhenkun, Zhang, Xin, Ding, Guipeng, Xu, Cheng, Xu, Jin, Jiang, Zhaoyan, Gu, Aihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Analogs Benzhydryl Compounds - toxicity Bisphenol A Bisphenol analogs Cell Survival - drug effects Deposition Evaluation Fatty acids Gene Expression - drug effects Genes Hep G2 Cells Hepatic lipid accumulation High-content screening (HCS) High-Throughput Screening Assays Humans In vitro evaluation Lipid deposition Lipid Metabolism - drug effects Lipids Liver Liver - metabolism Nuclear engineering Nuclear receptors Nuclear safety Oxidation Phenols - toxicity Screening Tetrabromobisphenol A Triglycerides
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Beschreibung
Zusammenfassung:	Bisphenol A (BPA) has a variety of adverse effects on human health; therefore, BPA analogs are increasingly used as replacements. Notably, recent studies have revealed that BPA exposure induced hepatic lipid accumulation, but few studies are available regarding the similar effects of other bisphenol analogues (BPs). Thus, in the present study, a high-content screening (HCS) assay was performed to simultaneously evaluate the hepatic lipid accumulation of 13 BPs in vitro. The BPs induced lipid deposition in HepG2 cells ranking as below: 4,4′-thiodiphenol (TDP)
ISSN:	0887-2333 1879-3177
DOI:	10.1016/j.tiv.2020.104959