Protecting-group-free synthesis of hydroxyesters from amino alcohols

The synthesis of hydroxyesters from carboxylic acids and unprotected amino alcohols in both continuous flow and batch processes is reported. The formation of a transient diazonium species with a dinitrite reagent is key in this transformation. The reaction conditions are compatible with a variety of...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2020-09, Vol.56 (74), p.1938-1941
Hauptverfasser:	Reynard, Guillaume, Joseph-Valcin, Eve-Marline, Lebel, Hélène
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Amino Alcohols - chemistry Batch processes Batch processing Carboxylic acids Carboxylic Acids - chemistry Continuous flow Esterification Esters - chemical synthesis Functional groups Reagents Synthesis
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The synthesis of hydroxyesters from carboxylic acids and unprotected amino alcohols in both continuous flow and batch processes is reported. The formation of a transient diazonium species with a dinitrite reagent is key in this transformation. The reaction conditions are compatible with a variety of functional groups. The synthesis of hydroxyesters from carboxylic acids and unprotected amino alcohols in both continuous flow and batch processes is reported.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/d0cc03242e