Avobenzone incorporation in a diverse range of Ru() scaffolds produces potent potential antineoplastic agents

Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2020-09, Vol.49 (35), p.12161-12167
Hauptverfasser:	Ryan, Raphael T, Havrylyuk, Dmytro, Stevens, Kimberly C, Moore, L. Henry, Kim, Doo Young, Blackburn, Jessica S, Heidary, David K, Selegue, John P, Glazer, Edith C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Coordination Complexes - chemistry Coordination Complexes - pharmacology Humans Ligands Light irradiation Photochemotherapy Photodynamic therapy Propiophenones - chemistry Reagents Ruthenium - chemistry Ruthenium compounds Structure-Activity Relationship Toxicity
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Zusammenfassung:	Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy. Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand.
ISSN:	1477-9226 1477-9234
DOI:	10.1039/d0dt02016h