Formal [5+2] Cycloaddition of Vinyloxiranes with Oxazol‐5‐(4H)‐ones: A Facile Approach for Construction of Seven‐Membered Lactones

The formal [5+2] cycloaddition of vinyloxiranes with oxazol‐5‐(4H)‐ones proceeds readily at room temperature in THF in the presence of Pd2(dba)3·CHCl3, dppp, and K2CO3, thus furnishing the desired seven‐membered lactones in 67–96 % yield. The chemical structure of the title compounds was confirmed b...

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Veröffentlicht in:European journal of organic chemistry 2020-09, Vol.2020 (34), p.5557-5562
Hauptverfasser: Zhao, Hong‐Wu, Ding, Wan‐Qiu, Wang, Li‐Ru, Guo, Jia‐Ming, Song, Xiu‐Qing, Wu, Hui‐Hui, Tang, Zhe, Fan, Xiao‐Zu, Bi, Xiao‐Fan
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Sprache:eng
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Zusammenfassung:The formal [5+2] cycloaddition of vinyloxiranes with oxazol‐5‐(4H)‐ones proceeds readily at room temperature in THF in the presence of Pd2(dba)3·CHCl3, dppp, and K2CO3, thus furnishing the desired seven‐membered lactones in 67–96 % yield. The chemical structure of the title compounds was confirmed by X‐ray diffraction analysis. The formal [5+2] cycloaddition of vinyloxiranes with oxazol‐5‐(4H)‐ones proceeds readily at room temperature in THF in the presence of Pd2(dba)3·CHCl3, dppp, and K2CO3, thus furnishing the desired seven‐membered lactones in 67–96 % yield. The chemical structure of the title compounds was confirmed by X‐ray diffraction analysis.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202000914