Formulation development and In vitro characterization of solid lipid nanoparticles of felbamate

Based on preliminary experiments and on literature, the influence of independent variable parameters selected were lipid (X1), surfactant (X2), and co-surfactant concentration (X3), aqueous phase volume (X4),magnetic stirrer rate (X5), probe sonication duration (X6), volume of beaker used for sonication (X7), volume of cold aqueous phase (X8) on the dependent variable such as particle surface area (Y1) was studied. [...]of the reduction in the sizes of NPs, the nano-carrier system presents a large surface area that can carry large dosages of drugs, efficiently decrease the peripheral toxicity of drugs, and provide adequate delivery of drugs to their targets [7]. [...]prudent to minimize the total number of experiments done in the optimization process, without sacrificing the quality of prepared Felbamate solid lipid nanoparticles. Based on preliminary experiments and on literature, the influence of independent variable parameters selected were lipid (X1), surfactant (X2), and co-surfactant concentration (X3), aqueous phase volume (X4), magnetic stirrer rate (X5), probe sonication duration (Xe), volume of beaker used for sonication (X7), volume of cold aqueous phase (Xg) on the dependent variable such as average particle surface area (Yl) of the formulated Felbamate loaded solid lipid nanoparticles (Table 1) was studied.Other parameters, i.e., magnetic stirrer rate and probe sonicator duration were not having a significant impact on particle size and their levels were kept constant for all the experiments.