A new rp-hplc method development and validation of paracetamol and aceclofenac in tablets by separating diclofenac

A new simple precise, accurate and selective RP-HPLC method was developed for the simultaneous estimation of Paracetamol and Aceclofenac in their mixed formulation by separating Diclofenac. Many formulations are available with many trade names. numorous methods have been reported simultaneously or in combination with other drugs including simultaneous estimation of Paracetamol and aceclofenac by spectrophotometric4, simultaneous estimation by HPLC5-9, Simultaneous estimation of rabeprazole and aceclofenac by HPLC10-12, simultaneous estimation of thiocolchicoside and aceclofenac RPUPLC13, simultaneous estimation of tizanidine and aceclofenac by HPLC14, simultaneous estimation of aceclofenac, paracetamol and chlorzozazone by HPLC, HPTLC and UHPLC15-23, simultaneous estimation of paracetamol, aceclofenac and rabeprazole sodium by HPLC and UV24-26, Simultaneous Estimation of Paracetamol, Aceclofenac and Serratiopeptidase by HPLC27-29, Paracetamol, Aceclofenac and Thiocolchicoside by HPLC and UV30,33, Simultaneous Determination of Aceclofenac, Paracetamol and Tramadol Hydrochloride by HPLC34-36, Simultaneous Determination of Some Anti-Inflammatory and Analgesic Drugs UHPLC37, from literature38-42 reveals Diclofenac is the degradation of Aceclofenac. A new, specific, selective, linear, accurate and precise isocratic RP-HPLC method was developed for the estimation of Paracetamol and Aceclofenac in their pharmaceutical tablet formulation in presence of Diclofenac. [...]the developed method could be adapted to regular quality control analysis and stability analysis.