An influence of lyophilization on praziquantel loaded nanosponge's by using food protein as a stabilizer with effect of statistical optimization

Nanosponge of different ratios were prepared by emulsion solvent diffusion method by using ethyl cellulose (X1) and PVA / whey protein was used as polymers, dichloromethane (DCM) (X2) as a solvent and Stirring speed (X3) maintained for different batches. Furthermore, an optimal batch was selected from eight formulations by using 23factorial design and evaluated for bulk density, tapped density, angle of repose, compressibility Index, Carr's index, dissolution studies, Entrapment efficiency, production yield, compatibility studies, powder x-ray diffraction (P-XRD), Differential scanning colorimetric (DSC), particle size analysis etc. [...]nanosponge formulation using a variety of polymers was found to be a good alternative approach for increasing the dissolution rate of Praziquantel. Freeze dried -20°C for 24 hrs and stored in ambient temperature until further use. 23 factorial design: 23 factorial design which consist of the Ethyl cellulose (X1), dichloromethane (X2) and stirring speed (X3) was considered as independent variable while Particle size, % cumulative drug release and drug loading was considered as dependent variables.