Evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice

Objective We aimed to evaluate the effect of vitexin on some hematologic parameters and oxidative stress markers in lead-induced toxicity in mice. Methods Forty adult male albino mice were divided into five groups of eight animals comprising: control; Pb; vitexin; Pb + vitexin; and Pb + vitexin (post) groups. Blood samples collected were analyzed using an auto hematology analyzer for sixteen parameters including red cell distribution width (RDW), red blood cell (RBC), and white blood cell (WBC). The levels of oxidative stress markers were also assessed. Results In Pb-treated group, RDW, RBC, MCV, Hb, Hct, granulocytes, and blood lead level were significantly different from the control group as well as Pb + vitexin (post) group. In Pb + vitexin groups, MCHC, platelets, and lymphocytes counts were significantly different from the control group. There was no difference in MPV, MID, and WBC between the groups. MDA level in Pb-treated group was significantly high while SOD and GPx levels were low. In Pb + vitexin-treated groups, SOD and GPx levels were significantly high while MDA was low. Conclusion Pb-induced toxicity caused significant changes in the values of hematologic parameters and oxidative markers measured but vitexin was able to mitigate some of the changes. Some of the values were inconsistent with Pb intoxication.