Use of a Target‐Mediated Drug Disposition Model to Predict the Human Pharmacokinetics and Target Occupancy of GC1118, an Anti‐epidermal Growth Factor Receptor Antibody

GC1118 is an anti‐epidermal growth factor receptor (EGFR) monoclonal antibody that is currently under clinical development. In this study, the pharmacokinetics (PK) of GC1118 were modelled in monkeys to predict human PK and receptor occupancy (RO) profiles. The serum concentrations of GC1118 and its...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2017-03, Vol.120 (3), p.243-249
Hauptverfasser:	Park, Wan‐Su, Han, Seunghoon, Lee, Jongtae, Hong, Taegon, Won, Jonghwa, Lim, Yangmi, Lee, Kyuhyun, Byun, Han Yeul, Yim, Dong‐Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Humanized - blood Antibodies, Monoclonal, Humanized - pharmacokinetics Antineoplastic Agents - blood Antineoplastic Agents - pharmacology Cetuximab - blood Cetuximab - pharmacology Computer Simulation Dose-Response Relationship, Drug Drug dosages Epidermal growth factor Epidermal growth factor receptors Exponents Growth factors Humans Intravenous administration Intravenous infusion Macaca fascicularis Models, Biological Monkeys Monoclonal antibodies Occupancy Pharmacokinetics Pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptors Sensitivity analysis Synthesis Therapeutic targets
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