Effect of Dietary Calcium on Adipogenesis Program and Its Role in Adipocyte Dysfunction in Male Wistar Rats

Dietary calcium influences obesity-related adipocyte dysfunction by modulating body weight. The molecular mechanism behind this weight management is under intense investigation. In the present study, the authors investigated the effect of dietary calcium on peroxisome proliferator-activated receptor...

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Veröffentlicht in:	National Academy of Sciences, India. Proceedings. Section B. Biological Sciences India. Proceedings. Section B. Biological Sciences, 2020-09, Vol.90 (3), p.631-639
Hauptverfasser:	Das, Sandeep, Choudhuri, Dipayan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipogenesis Adipose tissue Behavioral Sciences Biomedical and Life Sciences Body weight Calcium (dietary) Calcium-binding protein Diet Enzymatic activity Fatty acid-binding protein Inflammation Interleukin 6 Life Sciences Lipase Lipid peroxidation Lipoprotein lipase Nucleic Acid Chemistry Oxidative stress Peroxisome proliferator-activated receptors Plant Biochemistry Protein expression Proteins Research Article Rodents Tumor necrosis factor-α
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Zusammenfassung:	Dietary calcium influences obesity-related adipocyte dysfunction by modulating body weight. The molecular mechanism behind this weight management is under intense investigation. In the present study, the authors investigated the effect of dietary calcium on peroxisome proliferator-activated receptor-γ (PPAR-γ)-mediated adipogenesis program and its role in adipocyte dysfunction by measuring the inflammatory and oxidative markers within the adipose tissue of male albino rats. Healthy male rats were fed with a control diet based on AIN-93, and either low-calcium (0.25%) or high-calcium (1.0%) diet for 90 days. A significant inverse ( p
ISSN:	0369-8211 2250-1746
DOI:	10.1007/s40011-019-01135-4