In Vitro Study of Degradation Behavior, Cytotoxicity, and Cell Adhesion of the Atactic Polylactic Acid for Biomedical Purposes

An atactic poly- d , l -lactide (PLA) is obtained via ring-opening polymerization (ROP) of lactide stereoisomers mixture catalyzed by the magnesium and calcium acenaphthylenebisamido complexes. The polymer is characterized by gel-permeation chromatography, NMR spectroscopy, and mass spectrometry. Th...

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Veröffentlicht in:Journal of polymers and the environment 2020-10, Vol.28 (10), p.2652-2660
Hauptverfasser: Morozov, Alexander G., Razborov, Danila A., Egiazaryan, Tatevik A., Baten’kin, Maxim A., Aleynik, Diana Ya, Egorikhina, Marfa N., Rubtsova, Yulia P., Charikova, Irina N., Chesnokov, Sergei A., Fedushkin, Igor L.
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Sprache:eng
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Zusammenfassung:An atactic poly- d , l -lactide (PLA) is obtained via ring-opening polymerization (ROP) of lactide stereoisomers mixture catalyzed by the magnesium and calcium acenaphthylenebisamido complexes. The polymer is characterized by gel-permeation chromatography, NMR spectroscopy, and mass spectrometry. The hydrolytic degradation behavior, cytotoxicity, and cell adhesion of the resulting PLA are evaluated. The polymer degrades in phosphate-buffered saline, releasing water-soluble low molecular products that significantly influence dermal fibroblast growth. Polymer demonstrates no cytotoxicity that, along with cell adhesion and their high proliferative activity toward the PLA obtained, proves its biocompatibility.
ISSN:1566-2543
1572-8919
DOI:10.1007/s10924-020-01803-x