Frontispiece: Light‐Activated Carbon Monoxide Prodrugs Based on Bipyridyl Dicarbonyl Ruthenium(II) Complexes

Photoactivatable carbon‐monoxide‐releasing molecules (photoCORMs) are currently being intensively explored as therapeutically relevant pro‐drugs because this approach may lead to a safe and controllable release of carbon monoxide. In this context, a green‐fluorescent ruthenium(II) complex was design...

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Veröffentlicht in:Chemistry : a European journal 2020-08, Vol.26 (48), p.n/a
Hauptverfasser: Geri, Stepan, Krunclova, Tereza, Janouskova, Olga, Panek, Jiri, Hruby, Martin, Hernández‐Valdés, Daniel, Probst, Benjamin, Alberto, Roger A., Mamat, Constantin, Kubeil, Manja, Stephan, Holger
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Sprache:eng
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Zusammenfassung:Photoactivatable carbon‐monoxide‐releasing molecules (photoCORMs) are currently being intensively explored as therapeutically relevant pro‐drugs because this approach may lead to a safe and controllable release of carbon monoxide. In this context, a green‐fluorescent ruthenium(II) complex was designed as carrier for carbon monoxide and as molecular probe for monitoring the uptake in cells. Irradiation with UV‐A light triggered the desired decarbonylation with a rather unexpected outcome. For more details see the Full Paper by H. Stephan, M. Kubeil, et al. on page 10992 ff.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202084864