Iron catalyzed ketoalkylation and ketoalkylation/etherification of styrenes initiated by selective C–C bond cleavage

Iron catalyzed ketoalkylation and ketoalkylation/etherification of styrenes initiated by selective C–C bond cleavage

An iron-catalyzed ketoalkyl-Heck-type coupling initiated by radical C–C bond cleavage is described. The features of this protocol include mild conditions (40 °C, free of ligands and bases), broad substrate scope, excellent functional group tolerance and stereoselectivity. Satisfactorily, this Fe-bas...

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Veröffentlicht in:Organic Chemistry Frontiers 2020-09, Vol.7 (17), p.2414-2418
Hauptverfasser: Suo, Meng-Ting, Yang, Shuo, Yang, Jun-Cheng, Liu, Ze-Yu, Zhang, Jun-Jie, Guo, Li-Na
Format: Artikel
Sprache:eng
Schlagworte:
Cleavage
Covalent bonds
Functional groups
Iron
Organic chemistry
Stereoselectivity
Styrenes
Substrates
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Zusammenfassung:An iron-catalyzed ketoalkyl-Heck-type coupling initiated by radical C–C bond cleavage is described. The features of this protocol include mild conditions (40 °C, free of ligands and bases), broad substrate scope, excellent functional group tolerance and stereoselectivity. Satisfactorily, this Fe-based catalytic system was also applicable for the three-component ketoalkylation/etherification of styrenes.
ISSN:2052-4129
2052-4110
2052-4129
2052-4110
DOI:10.1039/D0QO00671H