A Review on Methods of Preparation and Characterisation of the solid Lipid Nanoparticles
Solid Lipid nanoparticles are considered to be colloidal systems comprising of lipids, stabilizers and coating materials having a particle size range of 10-1000 nm and are in a spherical shape. Because of the less particle size, the SLNs offers greater surface area and increased drug loading capacit...
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| Veröffentlicht in: | Research journal of pharmacy and technology 2020, Vol.13 (7), p.3433-3441 |
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| container_title | Research journal of pharmacy and technology |
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| creator | Sujan, M. Naga Patil, Amit B Gowda, D. V. |
| description | Solid Lipid nanoparticles are considered to be colloidal systems comprising of lipids, stabilizers and coating materials having a particle size range of 10-1000 nm and are in a spherical shape. Because of the less particle size, the SLNs offers greater surface area and increased drug loading capacity. The only difference between the SLN and nanoemulsion is that the liquid lipid in the nanoemulsion is replaced by the solid lipid in the SLN. Since the SLNs are made up of lipids, they have greater biocompatibility when compared to the polymeric nanoparticles. Dispersion is achieved by adding the melt to hot aqueous surfactant solution with continuous stirring Homogenisation with piston gap homogeniser and the formed emulsion was allowed to cool to room temperature leading to the formation of SLN. |
| doi_str_mv | 10.5958/0974-360X.2020.00610.1 |
| format | Article |
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| ispartof | Research journal of pharmacy and technology, 2020, Vol.13 (7), p.3433-3441 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aqueous solutions Biocompatibility Cooling Homogenization Lipids Manufacturing Methods Nanoemulsions Nanoparticles Particle size Pharmaceutical industry Solvents Surfactants Ultrasonic imaging |
| title | A Review on Methods of Preparation and Characterisation of the solid Lipid Nanoparticles |
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