Cardioprotective activity of Lawsonia inermis roots against Doxorubicin Treated Mice

Cardiotoxicity was evaluated by measuring serum biomarkers glutamic oxalo transaminase (GOT), glutamic Pyruvic transaminase (GPT), alkaline phosphatase (ALP), creatinine and urea and cardiac antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and lipid peroxidation (LP) in heart homogenate. DOX is one such anthracyclic anticancer agent widely used in the treatment of a variety of human malignancies including breast cancer, small cell carcinoma of the lungs and acute leukemia's[2]. [...]usage of these agents has been limited due to significant toxicities of their own and interference with anticancer property of DOX[6]. [...]a need is felt for an agent, which can protect DOX induced acute and chronic cardiotoxicity without compromising with DOX antineoplastic activity. Determination of lipid peroxidation and reduced glutathione levels: LP was measured in heart homogenate according to the method which is based on the formation of thiobarbituric acid reactive substances (TBARS) and expressed as the extent of malondialdehyde (MDA) production [18,19].