68Ga and 45Ti production on a GE PETtrace cyclotron using the ALCEO solid target

Objectives: The ALCEO solid target system has been developed by Comecer for cyclotron production of 64Cu 89Zr, 123I and 124I. ALCEO Solid Target is composed by one irradiation unit (PTS), one dissolution/transfer unit (EDS/FDS) and one purification module (TADDEO PRF); all the units work automatically, avoiding any radiation exposures to operators. Many sites are already producing these radioisotopes with yields respectively of >2mCi/µAh (64Cu), >0.4mCi/µAh (89Zr and 123I), >0.1mCi/µAh (124I). The aim of this work was to expand the use of the ALCEO system to also produce 68Ga and 45Ti. Production and labelling results will be presented as well. Methods 68Zn was electroplated onto a target shuttle and irradiated (with a typical current from 10µA to 30µA) with 12.1 MeV protons to produce 68Ga. Irradiated target was dissolved in 10M HCl. The 68Ga was separated from the irradiated 68Zn using LN resin (TRISKEM), then labelled to PSMA and DOTATATE using an Eckert and Ziegler Modular-Lab eazy synthesis module. Natural scandium was irradiated with 12.1 MeV protons, with a typical current of 10µA to produce 45Ti. Irradiated target was dissolved by drop-by-drop 6M HCl. The 45Ti was separated from the irradiated scandium using ZR resin (TRISKEM), then labelled manually to DFO mesylate salt . Results 68Ga is produced with a saturation yield of 1330±590 MBq/µA (N=2), and was successfully labelled to PSMA and DOTATATE with 79.2% and 76.0% synthesis yields and 99.0% and 91.3% radiochemical purity respectively. 45Ti is produced with a saturation yield of 312 MBq/µA (N=1). It was not successfully labelled to PSMA and DOTATATE, however the labelling efficiency for DFO mesylate salt was 41%. Conclusions The Comecer ALCEO solid target system has been used successfully to produce 64Cu, 89Zr, 68Ga and 45Ti. The produced PET-isotopes have a very high radio-purity and chemical-purity and they can be used for radio-labeling processes. Future work includes optimisation of separation processes, and production of 203Pb and 44Sc.