Formulation and In Vitro Evaluation of Doxophylline Oral Disintegrating Tablets

[...]in this investigation an attempt was made to develop oral disintegrating tablets of Doxofylline with super disintegrating agents like Sodium starch glycolate (SSG), Crospovidone and Ac-Di-Sol. The disintegration time for ODTs generally ranges from several seconds to about a minute.3'4 5 The ideal characteristics of a drug for oral dispersible tablet include * Ability to permeate the oral mucosa. * Very bitter or unacceptable taste and odor drugs are unsuitable for ODT6 Desired criteria for ODTs: * ODT should leave minimal or no residue in mouth after oral administration, compatible with pleasing mouth feel. * Be portable and without fragility concern.7,8 MATERIALS: [...]concluded that F6 Formulation (containing Crospovidone) was optimized better formulation.