Thermosensitive Nanoparticles Based on Polyethylenimine as Promising Materials for Biomedical Applications

Thermosensitive Nanoparticles Based on Polyethylenimine as Promising Materials for Biomedical Applications

Thermosensitive nanoparticles were synthesized by acylation of branched polyethyleneimine with isobutyroyl chloride and cross-linking by 1,6-hexamethylene diisocyanate. It was found that colloidal aqueous solutions of these particles reversibly lose solubility around physiological temperature. The i...

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Veröffentlicht in:Russian journal of general chemistry 2020-07, Vol.90 (7), p.1312-1316
Hauptverfasser: Tenkovtsev, A. V., Kurlykin, M. P., Amirova, A. I., Krasova, A. S., Kirila, T. Yu, Filippov, A. P.
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Aqueous solutions
Biomedical materials
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Crosslinking
Drug delivery systems
Drugs
Hexamethylene diisocyanate
Isocyanates
Nanoparticles
Phase transitions
Physiological aspects
Polyethyleneimine
Technology application
Vehicles
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Zusammenfassung:Thermosensitive nanoparticles were synthesized by acylation of branched polyethyleneimine with isobutyroyl chloride and cross-linking by 1,6-hexamethylene diisocyanate. It was found that colloidal aqueous solutions of these particles reversibly lose solubility around physiological temperature. The influence of the composition of the nanoparticle on their hydrodynamic parameters, as well as on the phase transition temperatures in aqueous solutions was evaluated.
ISSN:1070-3632
1608-3350
DOI:10.1134/S107036322007018X