Synthesis of 5-(Het)arylidene-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one Derivatives and Study of Their Antitumor and Anti-Inflammatory Activity

Synthesis of 5-(Het)arylidene-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one Derivatives and Study of Their Antitumor and Anti-Inflammatory Activity

The reaction of aromatic and heteroaromatic aldehydes with 3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one was studied. A series of new 5-(het)arylidene-3[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-ones was obtained. For synthesized compounds, antitumor and anti-inflammatory activity w...

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Veröffentlicht in:Russian journal of general chemistry 2020-07, Vol.90 (7), p.1207-1215
Hauptverfasser: Horishny, V. Ya, Chaban, T. I., Matiychuk, V. S.
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Anticancer properties
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Zusammenfassung:The reaction of aromatic and heteroaromatic aldehydes with 3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one was studied. A series of new 5-(het)arylidene-3[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-ones was obtained. For synthesized compounds, antitumor and anti-inflammatory activity was studied. Hit-compounds were identified that exceeded the known comparison drugs in their action.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363220070063