Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas

Background The usefulness of 5-aminolevulinic acid (5-ALA)–mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed. However, data about kinetics of 5-ALA and protoporphyrin (Pp) IX in meningiomas are lacking. Methods As the first study so far, we performed longitudinal intra...

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Veröffentlicht in:	Acta neurochirurgica 2020-09, Vol.162 (9), p.2197-2202
Hauptverfasser:	Kaneko, Sadahiro, Brokinkel, Benjamin, Suero Molina, Eric, Warneke, Nils, Holling, Markus, Bunk, Eva Christina, Hess, Katharina, Senner, Volker, Paulus, Werner, Stummer, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminolevulinic acid Aminolevulinic Acid - administration & dosage Aminolevulinic Acid - pharmacokinetics Brain cancer Brain tumors Comparative analysis Fluorescence Glioblastoma - surgery Humans Interventional Radiology Kinetics Medicine Medicine & Public Health Meningeal Neoplasms - surgery Meningioma - surgery Minimally Invasive Surgery Neurology Neuroradiology Neurosurgery Original Article - Brain Tumors Photosensitizing Agents - administration & dosage Photosensitizing Agents - pharmacokinetics Protoporphyrin Protoporphyrin IX Protoporphyrins - administration & dosage Protoporphyrins - pharmacokinetics Spectroscopy Surgery Surgery, Computer-Assisted - methods Surgical Orthopedics
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