Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas

Background The usefulness of 5-aminolevulinic acid (5-ALA)–mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed. However, data about kinetics of 5-ALA and protoporphyrin (Pp) IX in meningiomas are lacking. Methods As the first study so far, we performed longitudinal intra...

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Veröffentlicht in:	Acta neurochirurgica 2020-09, Vol.162 (9), p.2197-2202
Hauptverfasser:	Kaneko, Sadahiro, Brokinkel, Benjamin, Suero Molina, Eric, Warneke, Nils, Holling, Markus, Bunk, Eva Christina, Hess, Katharina, Senner, Volker, Paulus, Werner, Stummer, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminolevulinic acid Aminolevulinic Acid - administration & dosage Aminolevulinic Acid - pharmacokinetics Brain cancer Brain tumors Comparative analysis Fluorescence Glioblastoma - surgery Humans Interventional Radiology Kinetics Medicine Medicine & Public Health Meningeal Neoplasms - surgery Meningioma - surgery Minimally Invasive Surgery Neurology Neuroradiology Neurosurgery Original Article - Brain Tumors Photosensitizing Agents - administration & dosage Photosensitizing Agents - pharmacokinetics Protoporphyrin Protoporphyrin IX Protoporphyrins - administration & dosage Protoporphyrins - pharmacokinetics Spectroscopy Surgery Surgery, Computer-Assisted - methods Surgical Orthopedics
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Zusammenfassung:	Background The usefulness of 5-aminolevulinic acid (5-ALA)–mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed. However, data about kinetics of 5-ALA and protoporphyrin (Pp) IX in meningiomas are lacking. Methods As the first study so far, we performed longitudinal intraoperative real-time ex situ measurements of fluorescence intensity and PpIX concentrations during FGS of ten benign and two atypical meningiomas. Kinetics were subsequently compared with data from 229 glioblastomas. Results Spectroscopy revealed fluorescence (median 2945.65 a.u.) and PpIX accumulation (median 18.31 μg/ml) in all 43 analyzed samples. Fluorescence intensity (2961.50 a.u. vs 118.41 a.u.; p
ISSN:	0001-6268 0942-0940
DOI:	10.1007/s00701-020-04353-2