Hepatoprotective Activity of Leucas cephalotes against Paracetamol induced Hepatotoxicity in Rats
The principle causes of carbon tetrachloride is induced hepatic damage in lipid peroxidation and decreased activities of antioxidant enzymes and generation of free radicals. [...]on the 8th day single dose of Paracetamol 2g/kg was given to all group rats except rats in group I. On the 9th day, after...
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Veröffentlicht in: | Research journal of pharmacy and technology 2020-03, Vol.13 (3), p.1183-1186 |
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creator | Islam, G. Gahlot, Kavita Mani, Munesh Kumar, Prevesh Shukla, Divaker |
description | The principle causes of carbon tetrachloride is induced hepatic damage in lipid peroxidation and decreased activities of antioxidant enzymes and generation of free radicals. [...]on the 8th day single dose of Paracetamol 2g/kg was given to all group rats except rats in group I. On the 9th day, after 24 hours of Paracetamol administration blood samples were collected by direct cardiac puncture under light ether anesthesia. The drugs like Silymarin and the plant extract decreased increase enzyme levels in tested groups, indicating the protection of liver cell membrane or regeneration of damaged liver cells. Protective effect of pineapple (Ananas cosmosus) peel extract on alcohol-induced oxidative stress in brain tissues of male albino rats. |
doi_str_mv | 10.5958/0974-360X.2020.00218.8 |
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[...]on the 8th day single dose of Paracetamol 2g/kg was given to all group rats except rats in group I. On the 9th day, after 24 hours of Paracetamol administration blood samples were collected by direct cardiac puncture under light ether anesthesia. The drugs like Silymarin and the plant extract decreased increase enzyme levels in tested groups, indicating the protection of liver cell membrane or regeneration of damaged liver cells. Protective effect of pineapple (Ananas cosmosus) peel extract on alcohol-induced oxidative stress in brain tissues of male albino rats.</description><identifier>ISSN: 0974-3618</identifier><identifier>EISSN: 0974-360X</identifier><identifier>EISSN: 0974-306X</identifier><identifier>DOI: 10.5958/0974-360X.2020.00218.8</identifier><language>eng</language><publisher>Raipur: A&V Publications</publisher><subject>Analgesics ; Antioxidants ; Carbon ; Drug dosages ; Enzymes ; Herbal medicine ; Liver diseases ; Oxidative stress</subject><ispartof>Research journal of pharmacy and technology, 2020-03, Vol.13 (3), p.1183-1186</ispartof><rights>Copyright A&V Publications Mar 2020</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c198t-2c1c361a3a8b67a0c82b5012ec85a353aad818dbcf9db7df154a335681fbf1f33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Islam, G.</creatorcontrib><creatorcontrib>Gahlot, Kavita</creatorcontrib><creatorcontrib>Mani, Munesh</creatorcontrib><creatorcontrib>Kumar, Prevesh</creatorcontrib><creatorcontrib>Shukla, Divaker</creatorcontrib><title>Hepatoprotective Activity of Leucas cephalotes against Paracetamol induced Hepatotoxicity in Rats</title><title>Research journal of pharmacy and technology</title><description>The principle causes of carbon tetrachloride is induced hepatic damage in lipid peroxidation and decreased activities of antioxidant enzymes and generation of free radicals. 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Protective effect of pineapple (Ananas cosmosus) peel extract on alcohol-induced oxidative stress in brain tissues of male albino rats.</description><subject>Analgesics</subject><subject>Antioxidants</subject><subject>Carbon</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>Herbal medicine</subject><subject>Liver diseases</subject><subject>Oxidative stress</subject><issn>0974-3618</issn><issn>0974-360X</issn><issn>0974-306X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNo9kF1LwzAUhoMoOOb-ggS8bs1H06aXY6gTBoooeBdO00QztqY2qbh_b-pk5-Y9cN7z9SB0TUkuaiFvSV0VGS_Je84IIzkhjMpcnqHZqXB-yqm8RIsQtiRFKQUr5AzB2vQQfT_4aHR03wYvJ3HxgL3FGzNqCFib_hN2yREwfIDrQsTPMIA2EfZ-h13Xjtq0-Dgq-h-np37X4ReI4QpdWNgFs_jXOXq7v3tdrbPN08PjarnJNK1lzJimOp0IHGRTVkC0ZI0glBktBXDBAVpJZdtoW7dN1VoqCuBclJLaxlLL-RzdHOemX75GE6La-nHo0krFCk4Tl4qI5CqPLj34EAZjVT-4PQwHRYmaiKoJlprAqYmo-iOqJP8FeRVrGg</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Islam, G.</creator><creator>Gahlot, Kavita</creator><creator>Mani, Munesh</creator><creator>Kumar, Prevesh</creator><creator>Shukla, Divaker</creator><general>A&V Publications</general><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04S</scope><scope>04W</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20200301</creationdate><title>Hepatoprotective Activity of Leucas cephalotes against Paracetamol induced Hepatotoxicity in Rats</title><author>Islam, G. ; Gahlot, Kavita ; Mani, Munesh ; Kumar, Prevesh ; Shukla, Divaker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c198t-2c1c361a3a8b67a0c82b5012ec85a353aad818dbcf9db7df154a335681fbf1f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analgesics</topic><topic>Antioxidants</topic><topic>Carbon</topic><topic>Drug dosages</topic><topic>Enzymes</topic><topic>Herbal medicine</topic><topic>Liver diseases</topic><topic>Oxidative stress</topic><toplevel>online_resources</toplevel><creatorcontrib>Islam, G.</creatorcontrib><creatorcontrib>Gahlot, Kavita</creatorcontrib><creatorcontrib>Mani, Munesh</creatorcontrib><creatorcontrib>Kumar, Prevesh</creatorcontrib><creatorcontrib>Shukla, Divaker</creatorcontrib><collection>CrossRef</collection><collection>India Database</collection><collection>India Database: Business</collection><collection>India Database: Science & Technology</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Research journal of pharmacy and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Islam, G.</au><au>Gahlot, Kavita</au><au>Mani, Munesh</au><au>Kumar, Prevesh</au><au>Shukla, Divaker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatoprotective Activity of Leucas cephalotes against Paracetamol induced Hepatotoxicity in Rats</atitle><jtitle>Research journal of pharmacy and technology</jtitle><date>2020-03-01</date><risdate>2020</risdate><volume>13</volume><issue>3</issue><spage>1183</spage><epage>1186</epage><pages>1183-1186</pages><issn>0974-3618</issn><eissn>0974-360X</eissn><eissn>0974-306X</eissn><abstract>The principle causes of carbon tetrachloride is induced hepatic damage in lipid peroxidation and decreased activities of antioxidant enzymes and generation of free radicals. 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subjects | Analgesics Antioxidants Carbon Drug dosages Enzymes Herbal medicine Liver diseases Oxidative stress |
title | Hepatoprotective Activity of Leucas cephalotes against Paracetamol induced Hepatotoxicity in Rats |
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