Quality of Life and Increasing Role of Biomarkers in Diagnosis, Prognosis and Prediction of Diabetic Foot Ulcer

In current scenario biomarkers are playing a major role in drug discovery, preclinical pharmacological studies, clinical trials and post marketing studies.The general biomarker discussed in this review are transforming growth factor, procalcitonin, calprotectin, cystatinC, Osteoprotegerin-1, edothelin- 1, CXCL-6, CXCL-12, Epithelial neutrophil activator, hypoxia inducible factor-1, Growth factors, Nitric oxide, Stem progenitor cell, Matrix metalloproteinase, Fibrinogen and Serpin B3. The general biomarker discussed in this review are transforming growth factor, procalcitonin, calprotectin, cystatinC, Osteoprotegerin-1, edothelin- 1, CXCL-6, CXCL-12, Epithelial neutrophil activator, hypoxia inducible factor-1, Growth factors, Nitric oxide, Stem progenitor cell, Matrix metalloproteinase, Fibrinogen and Serpin B3. According to some authors PCT is more accurate than C- reactive protein [15]. According to this study the OPG levels has a positive correlation with wound healing in response to simvastatin drug [29].