Two novel milbemycin derivatives from the genetically engineered strain Streptomyces avermitilis AVE-H39

Two novel milbemycin derivatives from the genetically engineered strain Streptomyces avermitilis AVE-H39

Two novel milbemycin derivatives, 5,27-epoxy-13 α -hydroxy milbemycin β 11 ( 1 ) and 5,27-epoxy-13 α -hydroxy-25-ethyl milbemycin β 11 ( 2 ), were isolated from the genetically engineered strain Streptomyces avermitilis AVE-H39. Their structures were elucidated through the interpretation of HR-ESIMS...

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Veröffentlicht in:Journal of antibiotics 2020-09, Vol.73 (9), p.642-645
Hauptverfasser: Qi, Huan, Zhang, Ji, Hao, Zhi-Kui, Zhang, Shao-Yong, Li, Jian-Song, Zhang, Li-Qin, Wang, Ji-Dong, Xiang, Wen-Sheng
Format: Artikel
Sprache:eng
Schlagworte:
631/154/309/2132
631/154/309/2144
692/308/153
Acaricides - chemistry
Acaricides - pharmacology
Antinematodal Agents - chemistry
Antinematodal Agents - pharmacology
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Brief Communication
Genetic Engineering - methods
Life Sciences
Macrolides - chemistry
Macrolides - pharmacology
Magnetic Resonance Spectroscopy - methods
Medicinal Chemistry
Microbiology
Molecular Structure
Organic Chemistry
Streptomyces - metabolism
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Zusammenfassung:Two novel milbemycin derivatives, 5,27-epoxy-13 α -hydroxy milbemycin β 11 ( 1 ) and 5,27-epoxy-13 α -hydroxy-25-ethyl milbemycin β 11 ( 2 ), were isolated from the genetically engineered strain Streptomyces avermitilis AVE-H39. Their structures were elucidated through the interpretation of HR-ESIMS and extensive NMR spectroscopic data. Compounds 1 and 2 exhibited moderate acaricidal and nematicidal activities.
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-020-0317-2