Orodispersible Tablets: A Review

According to US FDA, ODT is a solid dosage form which contains drug substances that rapidly disintegrates when placed upon tongue usually disintegrates within a matter of second[8]. IDEAL PROPERTIES OF ORODISPERSIBLE TABLETS: * Requires no water for taking orally[7,17,18]. * ODT shows less sensitivity to environmental conditions and temperature. * High drug loading is allowed. * Less friable and have sufficient hardness[4]. * After administration it should not leave any or minimal residue in the mouth. * ODTs should produce pleasing, acceptable mouth feel and taste masking of drug incorporated. * Method of production should be cost effective. * Preparation and packaging must be done through conventional methods. ADVANTAGES: * It's easier way of administration is the major advantage for the patients who have problem with swallowing of drugs such as patients in shock state, stroke victim, bedridden patients, patients who are suffering from kidney failure, pediatric, geriatric patients[28,29]. * Produces pleasant taste effect that change the medication perception. Swelling: In this mechanism disintegrating agent starch imparts the disintegrating effect. Because of inadequate swelling force, highly porous tablets shows less disintegration whereas with sufficient force the tablets show low porosity with good disintegration.