Short Chain Fatty Acids Modulate the Growth and Virulence of Pathosymbiont Escherichia coli and Host Response

Short Chain Fatty Acids Modulate the Growth and Virulence of Pathosymbiont Escherichia coli and Host Response

Short chain fatty acids (SCFA), principally acetate, propionate, and butyrate, are produced by fermentation of dietary fibers by the gut microbiota. SCFA regulate the growth and virulence of enteric pathogens, such as enterohemorrhagic E. coli (EHEC), Klebsiella and Salmonella. We sought to investig...

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Veröffentlicht in:Antibiotics (Basel) 2020-08, Vol.9 (8), p.462, Article 462
Hauptverfasser: Zhang, Shiying, Dogan, Belgin, Guo, Cindy, Herlekar, Deepali, Stewart, Katrina, Scherl, Ellen J., Simpson, Kenneth W.
Format: Artikel
Sprache:eng
Schlagworte:
Acetic acid
adherent invasive E. coli (AIEC), colorectal cancer (CRC), pathosymbiont
Agglutination
Bacteria
Bacterial diseases
Carbohydrates
Colon
Colorectal carcinoma
Diet
Disease
E coli
Epithelial cells
Escherichia coli
Fatty acids
Fermentation
Fibers
Functional analysis
Gene expression
Health aspects
Host-bacteria relationships
Infectious Diseases
Infectivity
Inflammation
Inflammatory bowel disease
inflammatory bowel disease (IBD), Crohn’s disease (CD)
Inflammatory bowel diseases
Interleukin 8
Intestinal microflora
Intestine
invasion
Klebsiella
Large intestine
Life Sciences & Biomedicine
Metabolism
Microbiota
motility
NF-κB protein
Observations
pH effects
Pharmacology & Pharmacy
Propionic acid
Salmonella
Science & Technology
short chain fatty acids (SCFA)
Signal transduction
Virulence
Virulence (Microbiology)
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Zusammenfassung:Short chain fatty acids (SCFA), principally acetate, propionate, and butyrate, are produced by fermentation of dietary fibers by the gut microbiota. SCFA regulate the growth and virulence of enteric pathogens, such as enterohemorrhagic E. coli (EHEC), Klebsiella and Salmonella. We sought to investigate the impact of SCFA on growth and virulence of pathosymbiontE. coliassociated with inflammatory bowel disease (IBD) and colorectal cancer (CRC), and their role in regulating host responses to bacterial infection in vitro. We found that under ileal conditions (pH=7.4; 12 mM total SCFA), SCFA significantly (p
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics9080462