Efficacy and safety of nivolumab for renal cell carcinoma in patients over 75 years old from multiple Japanese institutes

Purpose Despite nivolumab being increasingly used for treating metastatic renal cell carcinoma (mRCC), differing findings have been reported about its efficacy and safety in elderly patients. Thus, this study was aimed at evaluating nivolumab’s efficacy and safety for treating mRCC in Japanese patie...

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Veröffentlicht in:	International journal of clinical oncology 2020-08, Vol.25 (8), p.1543-1550
Hauptverfasser:	Numakura, Kazuyuki, Kobayashi, Mizuki, Hatakeyama, Shingo, Naito, Sei, Horikawa, Yohei, Tanaka, Toshikazu, Kamada, Sachiko, Muto, Yumina, Yamamoto, Ryohei, Koizumi, Atsushi, Nara, Taketoshi, Kanda, Sohei, Saito, Mitsuru, Narita, Shintaro, Inoue, Takamitsu, Shimoda, Naotake, Tsuchiya, Norihiko, Ohyama, Chikara, Habuchi, Tomonori
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Cancer Research Immunotherapy Kidney cancer Life Sciences & Biomedicine Medicine Medicine & Public Health Metastases Monoclonal antibodies Oncology Original Article Patients Renal cell carcinoma Safety Science & Technology Surgical Oncology Targeted cancer therapy
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Zusammenfassung:	Purpose Despite nivolumab being increasingly used for treating metastatic renal cell carcinoma (mRCC), differing findings have been reported about its efficacy and safety in elderly patients. Thus, this study was aimed at evaluating nivolumab’s efficacy and safety for treating mRCC in Japanese patients aged ≥ 75 years. Methods From March 2013 to August 2019, 118 mRCC patients (89 men and 29 women) were treated with nivolumab. The objective response rates (ORRs) were compared between patients aged ≥ 75 and
ISSN:	1341-9625 1437-7772
DOI:	10.1007/s10147-020-01693-y