A Darker Side to Retinoic Acid Revealed by Sarcomas

A Darker Side to Retinoic Acid Revealed by Sarcomas

A recent study of mouse models and human sarcoma tissue implicates retinoic acid, produced by the tumor cells of sarcomas, in blunting antitumor immune mechanisms.

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Bibliographische Detailangaben
Veröffentlicht in:The New England journal of medicine 2020-07, Vol.383 (5), p.491-493
1. Verfasser: Balkwill, Frances R
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Animal models
Antigens
Antitumor activity
Cytokines
Dendritic cells
Enzymes
Leukemia
Neutrophils
Proteins
Retinoic acid
Sarcoma
Tumor cells
Tumors
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Beschreibung
Zusammenfassung:A recent study of mouse models and human sarcoma tissue implicates retinoic acid, produced by the tumor cells of sarcomas, in blunting antitumor immune mechanisms.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMcibr2005538