Pleurocorols A and B: rearranged steroids from the fruiting bodies of Pleurotus cornucopiae
Pleurocorols A ( 1 ) and B ( 2 ) with unprecedented carbon skeletons were isolated from the fruiting bodies of Pleurotus cornucopiae . The structures of compounds 1 and 2 were determined by using spectroscopic data and X-ray crystallography as 11(9 → 8) abeo -ergostane and 5(6 → 7), 11(9 → 7)di abeo...
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| Veröffentlicht in: | Organic Chemistry Frontiers 2020-01, Vol.7 (15), p.2022-2028 |
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| container_title | Organic Chemistry Frontiers |
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| creator | Kikuchi, Takashi Mori, Maki In, Yasuko Zhang, Jie Yamada, Takeshi Hirano, Tomoya |
| description | Pleurocorols A (
1
) and B (
2
) with unprecedented carbon skeletons were isolated from the fruiting bodies of
Pleurotus cornucopiae
. The structures of compounds
1
and
2
were determined by using spectroscopic data and X-ray crystallography as 11(9 → 8)
abeo
-ergostane and 5(6 → 7), 11(9 → 7)di
abeo
-ergostane steroids, respectively. Their inhibitory effect on nitric oxide production and their cytotoxic activity against cancer cell lines were evaluated. |
| doi_str_mv | 10.1039/D0QO00605J |
| format | Article |
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1
) and B (
2
) with unprecedented carbon skeletons were isolated from the fruiting bodies of
Pleurotus cornucopiae
. The structures of compounds
1
and
2
were determined by using spectroscopic data and X-ray crystallography as 11(9 → 8)
abeo
-ergostane and 5(6 → 7), 11(9 → 7)di
abeo
-ergostane steroids, respectively. Their inhibitory effect on nitric oxide production and their cytotoxic activity against cancer cell lines were evaluated.</description><identifier>ISSN: 2052-4129</identifier><identifier>ISSN: 2052-4110</identifier><identifier>EISSN: 2052-4129</identifier><identifier>EISSN: 2052-4110</identifier><identifier>DOI: 10.1039/D0QO00605J</identifier><language>eng</language><publisher>London: Royal Society of Chemistry</publisher><subject>Crystallography ; Cytotoxicity ; Fruit bodies ; Nitric oxide ; Organic chemistry ; Pleurotus cornucopiae ; Steroid hormones ; Steroids ; Tumor cell lines ; X-ray crystallography</subject><ispartof>Organic Chemistry Frontiers, 2020-01, Vol.7 (15), p.2022-2028</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c240t-8f7faaa07aa70642e58854c90b9897d0c5b627ab90c287b909e0774f4d6739923</citedby><cites>FETCH-LOGICAL-c240t-8f7faaa07aa70642e58854c90b9897d0c5b627ab90c287b909e0774f4d6739923</cites><orcidid>0000-0001-8832-5720 ; 0000-0003-1779-1075 ; 0000-0003-1196-7199</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Kikuchi, Takashi</creatorcontrib><creatorcontrib>Mori, Maki</creatorcontrib><creatorcontrib>In, Yasuko</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Yamada, Takeshi</creatorcontrib><creatorcontrib>Hirano, Tomoya</creatorcontrib><title>Pleurocorols A and B: rearranged steroids from the fruiting bodies of Pleurotus cornucopiae</title><title>Organic Chemistry Frontiers</title><description>Pleurocorols A (
1
) and B (
2
) with unprecedented carbon skeletons were isolated from the fruiting bodies of
Pleurotus cornucopiae
. The structures of compounds
1
and
2
were determined by using spectroscopic data and X-ray crystallography as 11(9 → 8)
abeo
-ergostane and 5(6 → 7), 11(9 → 7)di
abeo
-ergostane steroids, respectively. Their inhibitory effect on nitric oxide production and their cytotoxic activity against cancer cell lines were evaluated.</description><subject>Crystallography</subject><subject>Cytotoxicity</subject><subject>Fruit bodies</subject><subject>Nitric oxide</subject><subject>Organic chemistry</subject><subject>Pleurotus cornucopiae</subject><subject>Steroid hormones</subject><subject>Steroids</subject><subject>Tumor cell lines</subject><subject>X-ray crystallography</subject><issn>2052-4129</issn><issn>2052-4110</issn><issn>2052-4129</issn><issn>2052-4110</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpNkE1LxDAURYMoOIyz8RcE3AnV1zRpGnfj-M3AKOjKRUnTZOzQaepLu_DfG6mgq3sXh3PhEnKawkUKmbq8gZcNQA7i6YDMGAiW8JSpw3_9mCxC2AFAykTk5Iy8P7d2RG88-jbQJdVdTa-vKFqNqLutrWkYLPqmDtSh39Phw8YyNkPTbWnl68YG6h2dLMMYaDR1o_F9o-0JOXK6DXbxm3Pydnf7unpI1pv7x9VynRjGYUgKJ53WGqTWEnLOrCgKwY2CShVK1mBElTOpKwWGFTKGsiAld7zOZaYUy-bkbPL26D9HG4Zy50fs4mTJOJOCKZ5lkTqfKIM-BLSu7LHZa_wqUyh__iv__su-AS0qYZo</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Kikuchi, Takashi</creator><creator>Mori, Maki</creator><creator>In, Yasuko</creator><creator>Zhang, Jie</creator><creator>Yamada, Takeshi</creator><creator>Hirano, Tomoya</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0001-8832-5720</orcidid><orcidid>https://orcid.org/0000-0003-1779-1075</orcidid><orcidid>https://orcid.org/0000-0003-1196-7199</orcidid></search><sort><creationdate>20200101</creationdate><title>Pleurocorols A and B: rearranged steroids from the fruiting bodies of Pleurotus cornucopiae</title><author>Kikuchi, Takashi ; Mori, Maki ; In, Yasuko ; Zhang, Jie ; Yamada, Takeshi ; Hirano, Tomoya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c240t-8f7faaa07aa70642e58854c90b9897d0c5b627ab90c287b909e0774f4d6739923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Crystallography</topic><topic>Cytotoxicity</topic><topic>Fruit bodies</topic><topic>Nitric oxide</topic><topic>Organic chemistry</topic><topic>Pleurotus cornucopiae</topic><topic>Steroid hormones</topic><topic>Steroids</topic><topic>Tumor cell lines</topic><topic>X-ray crystallography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kikuchi, Takashi</creatorcontrib><creatorcontrib>Mori, Maki</creatorcontrib><creatorcontrib>In, Yasuko</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Yamada, Takeshi</creatorcontrib><creatorcontrib>Hirano, Tomoya</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Organic Chemistry Frontiers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kikuchi, Takashi</au><au>Mori, Maki</au><au>In, Yasuko</au><au>Zhang, Jie</au><au>Yamada, Takeshi</au><au>Hirano, Tomoya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pleurocorols A and B: rearranged steroids from the fruiting bodies of Pleurotus cornucopiae</atitle><jtitle>Organic Chemistry Frontiers</jtitle><date>2020-01-01</date><risdate>2020</risdate><volume>7</volume><issue>15</issue><spage>2022</spage><epage>2028</epage><pages>2022-2028</pages><issn>2052-4129</issn><issn>2052-4110</issn><eissn>2052-4129</eissn><eissn>2052-4110</eissn><abstract>Pleurocorols A (
1
) and B (
2
) with unprecedented carbon skeletons were isolated from the fruiting bodies of
Pleurotus cornucopiae
. The structures of compounds
1
and
2
were determined by using spectroscopic data and X-ray crystallography as 11(9 → 8)
abeo
-ergostane and 5(6 → 7), 11(9 → 7)di
abeo
-ergostane steroids, respectively. Their inhibitory effect on nitric oxide production and their cytotoxic activity against cancer cell lines were evaluated.</abstract><cop>London</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/D0QO00605J</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8832-5720</orcidid><orcidid>https://orcid.org/0000-0003-1779-1075</orcidid><orcidid>https://orcid.org/0000-0003-1196-7199</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2052-4129 |
| ispartof | Organic Chemistry Frontiers, 2020-01, Vol.7 (15), p.2022-2028 |
| issn | 2052-4129 2052-4110 2052-4129 2052-4110 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Crystallography Cytotoxicity Fruit bodies Nitric oxide Organic chemistry Pleurotus cornucopiae Steroid hormones Steroids Tumor cell lines X-ray crystallography |
| title | Pleurocorols A and B: rearranged steroids from the fruiting bodies of Pleurotus cornucopiae |
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