A fluorescent molecular rotor probe for tracking plasma membranes and exosomes in living cells

A rotor-based probe MRMP-1 was designed and synthesized. MRMP-1 can bind to plasma membranes very quickly and stably with remarkable fluorescence enhancement. It can be used to monitor the dynamic changes in cell membranes in real-time under stimuli conditions. Importantly, MRMP-1 is the first rotor...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2020-07, Vol.56 (6), p.848-8483
Hauptverfasser:	Feng, Ling, Xie, Yusheng, Au-Yeung, Sung King, Hailu, Hagos Birhanu, Liu, Zhiyang, Chen, Qingxin, Zhang, Jie, Pang, Qiuxiang, Yao, Xi, Yang, Mengsu, Zhang, Liang, Sun, Hongyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Membrane - chemistry Cell Membrane - metabolism Cell membranes Cells (biology) Exosomes - chemistry Exosomes - metabolism Fluorescence Fluorescent Dyes - chemistry Humans Hydrogen Peroxide - chemistry Mice Microscopy, Confocal Rotors Spectrometry, Fluorescence
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Beschreibung
Zusammenfassung:	A rotor-based probe MRMP-1 was designed and synthesized. MRMP-1 can bind to plasma membranes very quickly and stably with remarkable fluorescence enhancement. It can be used to monitor the dynamic changes in cell membranes in real-time under stimuli conditions. Importantly, MRMP-1 is the first rotor-based fluorescent sensor to label exosomes in living cells. A rotor-based fluorescent probe to label exosomes in living cells.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/d0cc03069d