An MRI-visible immunoadjuvant based on hollow Gd2O3 nanospheres for cancer immunotherapy

An MRI-visible immunoadjuvant based on hollow Gd2O3 nanospheres for cancer immunotherapy

Hollow Gd2O3 nanospheres significantly promote the cellular uptake of a tumor antigen by antigen presenting cells, exhibit pH-dependent alteration of the MR signal intensity and markedly enhance the antitumor immunity. Hollow Gd2O3 nanospheres are promising as magnetic resonance imaging (MRI)-visibl...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-07, Vol.56 (59), p.8186-8189
Hauptverfasser: Li, Xia, Wang, Xiupeng, Ito, Atsuo
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Cancer
Gadolinium oxides
Immunotherapy
Magnetic resonance imaging
Nanospheres
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Zusammenfassung:Hollow Gd2O3 nanospheres significantly promote the cellular uptake of a tumor antigen by antigen presenting cells, exhibit pH-dependent alteration of the MR signal intensity and markedly enhance the antitumor immunity. Hollow Gd2O3 nanospheres are promising as magnetic resonance imaging (MRI)-visible cancer immunoadjuvants for cancer immunotherapy.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc03568h