Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts
In a randomized, double-blind trial that treated household contacts of patients with influenza with a single dose of baloxavir or placebo, participants taking baloxavir had a lower risk of influenza (1.9%) than placebo controls (13.6%). Adverse events were similar in the two groups.
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| Veröffentlicht in: | The New England journal of medicine 2020-07, Vol.383 (4), p.309-320 |
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| container_issue | 4 |
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| container_title | The New England journal of medicine |
| container_volume | 383 |
| creator | Ikematsu, Hideyuki Hayden, Frederick G Kawaguchi, Keiko Kinoshita, Masahiro de Jong, Menno D Lee, Nelson Takashima, Satoru Noshi, Takeshi Tsuchiya, Kenji Uehara, Takeki |
| description | In a randomized, double-blind trial that treated household contacts of patients with influenza with a single dose of baloxavir or placebo, participants taking baloxavir had a lower risk of influenza (1.9%) than placebo controls (13.6%). Adverse events were similar in the two groups. |
| doi_str_mv | 10.1056/NEJMoa1915341 |
| format | Article |
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All rights reserved.</rights><rights>Copyright © 2020 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-8c70553adbe6ca856abab3912742d3a5b2078da3c9465c09457dbf50a6eeb5c3</citedby><cites>FETCH-LOGICAL-c456t-8c70553adbe6ca856abab3912742d3a5b2078da3c9465c09457dbf50a6eeb5c3</cites><orcidid>0000-0002-0783-6607</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1915341$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1915341$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32640124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikematsu, Hideyuki</creatorcontrib><creatorcontrib>Hayden, Frederick G</creatorcontrib><creatorcontrib>Kawaguchi, Keiko</creatorcontrib><creatorcontrib>Kinoshita, Masahiro</creatorcontrib><creatorcontrib>de Jong, Menno D</creatorcontrib><creatorcontrib>Lee, Nelson</creatorcontrib><creatorcontrib>Takashima, Satoru</creatorcontrib><creatorcontrib>Noshi, Takeshi</creatorcontrib><creatorcontrib>Tsuchiya, Kenji</creatorcontrib><creatorcontrib>Uehara, Takeki</creatorcontrib><title>Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In a randomized, double-blind trial that treated household contacts of patients with influenza with a single dose of baloxavir or placebo, participants taking baloxavir had a lower risk of influenza (1.9%) than placebo controls (13.6%). Adverse events were similar in the two groups.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Antiviral Agents - administration & dosage</subject><subject>Antiviral Agents - adverse effects</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Antiviral drugs</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Dibenzothiepins</subject><subject>Disease Transmission, Infectious - prevention & control</subject><subject>Double-Blind Method</subject><subject>Drug resistance</subject><subject>Endonuclease</subject><subject>Endonucleases - antagonists & inhibitors</subject><subject>Family</subject><subject>Female</subject><subject>Fever</subject><subject>Households</subject><subject>Humans</subject><subject>Infections</subject><subject>Influenza</subject><subject>Influenza A</subject><subject>Influenza A virus - 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| subjects | Administration, Oral Adolescent Adult Age Aged Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Antiviral drugs Child Child, Preschool Clinical trials Confidence intervals Dibenzothiepins Disease Transmission, Infectious - prevention & control Double-Blind Method Drug resistance Endonuclease Endonucleases - antagonists & inhibitors Family Female Fever Households Humans Infections Influenza Influenza A Influenza A virus - genetics Influenza A virus - isolation & purification Influenza, Human - prevention & control Influenza, Human - transmission Influenza, Human - virology Intention to Treat Analysis Laboratories Male Middle Aged Morpholines Oxazines - administration & dosage Oxazines - adverse effects Oxazines - therapeutic use Patients Pediatrics Prophylaxis Pyridines - administration & dosage Pyridines - adverse effects Pyridines - therapeutic use Pyridones Reverse Transcriptase Polymerase Chain Reaction Thiepins - administration & dosage Thiepins - adverse effects Thiepins - therapeutic use Triazines - administration & dosage Triazines - adverse effects Triazines - therapeutic use Viruses |
| title | Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts |
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