Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts

In a randomized, double-blind trial that treated household contacts of patients with influenza with a single dose of baloxavir or placebo, participants taking baloxavir had a lower risk of influenza (1.9%) than placebo controls (13.6%). Adverse events were similar in the two groups.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2020-07, Vol.383 (4), p.309-320
Hauptverfasser:	Ikematsu, Hideyuki, Hayden, Frederick G, Kawaguchi, Keiko, Kinoshita, Masahiro, de Jong, Menno D, Lee, Nelson, Takashima, Satoru, Noshi, Takeshi, Tsuchiya, Kenji, Uehara, Takeki
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Age Aged Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Antiviral drugs Child Child, Preschool Clinical trials Confidence intervals Dibenzothiepins Disease Transmission, Infectious - prevention & control Double-Blind Method Drug resistance Endonuclease Endonucleases - antagonists & inhibitors Family Female Fever Households Humans Infections Influenza Influenza A Influenza A virus - genetics Influenza A virus - isolation & purification Influenza, Human - prevention & control Influenza, Human - transmission Influenza, Human - virology Intention to Treat Analysis Laboratories Male Middle Aged Morpholines Oxazines - administration & dosage Oxazines - adverse effects Oxazines - therapeutic use Patients Pediatrics Prophylaxis Pyridines - administration & dosage Pyridines - adverse effects Pyridines - therapeutic use Pyridones Reverse Transcriptase Polymerase Chain Reaction Thiepins - administration & dosage Thiepins - adverse effects Thiepins - therapeutic use Triazines - administration & dosage Triazines - adverse effects Triazines - therapeutic use Viruses
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Beschreibung
Zusammenfassung:	In a randomized, double-blind trial that treated household contacts of patients with influenza with a single dose of baloxavir or placebo, participants taking baloxavir had a lower risk of influenza (1.9%) than placebo controls (13.6%). Adverse events were similar in the two groups.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1915341