Catalyst-free regio- and chemoselective addition of secondary phosphine oxides to isoquinolines

Catalyst-free regio- and chemoselective addition of secondary phosphine oxides to isoquinolines

Isoquinolines react with secondary phosphine oxides without catalyst (70–75 °C, 10–15 h, without solvent or in MeCN) to chemo- and regioselectively form previously unknown diadducts, 1,3-bis(diorganylphosphoryl)-1,2,3,4-tetrahydroisoquinolines, in high yields (85–95%).

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Veröffentlicht in:Russian chemical bulletin 2020-06, Vol.69 (6), p.1102-1105
Hauptverfasser: Volkov, P. A., Gusarova, N. K., Telezhkin, A. A., Khrapova, K. O., Ivanova, N. I., Albanov, A. I., Vakul’skaya, T. I., Khutsishvili, S. S., Trofimov, B. A.
Format: Artikel
Sprache:eng
Schlagworte:
Catalysts
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Inorganic Chemistry
Organic Chemistry
Phosphine oxide
Phosphines
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Zusammenfassung:Isoquinolines react with secondary phosphine oxides without catalyst (70–75 °C, 10–15 h, without solvent or in MeCN) to chemo- and regioselectively form previously unknown diadducts, 1,3-bis(diorganylphosphoryl)-1,2,3,4-tetrahydroisoquinolines, in high yields (85–95%).
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-020-2874-8