Silatrane-containing poly(β-amino esters)

Silatrane-containing poly(β-amino esters)

A series of poly(β-amino esters) were synthesized using the Michael addition reaction from 1-(3-aminopropyl)silatrane and glycol diacrylates. The structure of the resulting olygomers was confirmed by means of 1 H NMR spectroscopy. Using acetylsalicylic acid as a model drug, the ability of synthesize...

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Veröffentlicht in:Russian chemical bulletin 2020-06, Vol.69 (6), p.1134-1137
Hauptverfasser: Istratov, V. V., Vasnev, V. A.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylsalicylic acid
Biological activity
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Esters
Full Articles
Inorganic Chemistry
Michael reaction
NMR spectroscopy
Organic Chemistry
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Zusammenfassung:A series of poly(β-amino esters) were synthesized using the Michael addition reaction from 1-(3-aminopropyl)silatrane and glycol diacrylates. The structure of the resulting olygomers was confirmed by means of 1 H NMR spectroscopy. Using acetylsalicylic acid as a model drug, the ability of synthesized olygomers to bind carboxyl-containing physiologically active compounds was shown. Synthesized polymers have been found to possess biological activity characteristic of low molecular 1-(3-aminopropyl)silatrane.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-020-2879-3