Efficacy and safety of subcutaneous administration of ceftazidime as a salvage therapy in geriatrics: a case report

Ceftazidime is a third‐generation cephalosporin used for the treatment of Gram‐negative bacteria only approved for parenteral use by intravenous and intramuscular route. In some clinical situations, off‐label subcutaneous injection could be a salvage route for the administration of antibiotics, espe...

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Veröffentlicht in:Fundamental & clinical pharmacology 2020-08, Vol.34 (4), p.521-524
Hauptverfasser: Michelon, Hugues, Tardivel, Marie, Dinh, Aurélien, Alvarez, Jean‐Claude, Salomon, Elsa, Le Quintrec, Jean‐Laurent, Hirt, Deborah, Davido, Benjamin
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Sprache:eng
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Zusammenfassung:Ceftazidime is a third‐generation cephalosporin used for the treatment of Gram‐negative bacteria only approved for parenteral use by intravenous and intramuscular route. In some clinical situations, off‐label subcutaneous injection could be a salvage route for the administration of antibiotics, especially in geriatrics, despite the paucity of evidence about efficacy and safety. We report a case of a successful and well‐tolerated subcutaneous ceftazidime therapy in a 90‐year‐old woman for the treatment of an acute urinary tract infection caused by Pseudomonas aeruginosa with therapeutic drug monitoring data.
ISSN:0767-3981
1472-8206
DOI:10.1111/fcp.12520