Protective effect of seabuckthorn berry juice against acrylamide‐induced oxidative damage in rats
Acrylamide (AA), classified as a probable carcinogen, can be neurotoxic, genotoxic, and can damage DNA. This study explored the ability of seabuckthorn berries juice (SBJ) to alleviate AA‐induced toxic injury in rats. Twenty‐four adult male Sprague‐Dawley (SD) rats were randomly divided into four gr...
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| Veröffentlicht in: | Journal of food science 2020-07, Vol.85 (7), p.2245-2254 |
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| creator | Zhao, Sijia Sun, Hongyang Liu, Qingbo Shen, Yu Jiang, Yujun Li, Yanhua Liu, Tong Liu, Tianxu Xu, Honghua Shao, Meili |
| description | Acrylamide (AA), classified as a probable carcinogen, can be neurotoxic, genotoxic, and can damage DNA. This study explored the ability of seabuckthorn berries juice (SBJ) to alleviate AA‐induced toxic injury in rats. Twenty‐four adult male Sprague‐Dawley (SD) rats were randomly divided into four groups: control group, AA group (40 mg/kg), AA + SBJ (40 mg/kg AA and 5 mL/kg SBJ), and AA + vitamin C (VC) group (positive control group, 40 mg/kg AA and 100 mg/kg VC). At the end of the experiment, rats in AA group showed a marked decrease in the rate of weight gain, hind extremity abduction, and ataxia. Obvious anomalies were seen in plasma biochemical parameters (P |
| doi_str_mv | 10.1111/1750-3841.15313 |
| format | Article |
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Practical Application
Seabuckthorn berries are wild berries rich in vitamin C and polyphenols, which have good antioxidant properties. In this experiment, SBJ has a significant alleviating effect on AA‐induced oxidative damage in rats. Therefore, we speculate that SBJ may relieve the oxidative damage caused by diet or other forms of AA exposure in the general population. At the same time, this experiment also provides new ideas for alleviating AA‐induced in vivo toxicity.</description><identifier>ISSN: 0022-1147</identifier><identifier>EISSN: 1750-3841</identifier><identifier>DOI: 10.1111/1750-3841.15313</identifier><language>eng</language><publisher>Chicago: Wiley Subscription Services, Inc</publisher><subject>Acrylamide ; Anomalies ; Antioxidants ; Ascorbic acid ; Ataxia ; Berries ; Biocompatibility ; Body weight gain ; Carcinogens ; Catalase ; Cerebellum ; Damage ; DNA damage ; Experiments ; Fruits ; Genotoxicity ; Glutathione ; Hippophae ; in vivo ; Intestine ; Kidneys ; Malondialdehyde ; Neurotoxicity ; oxidative damage ; Polyphenols ; rats ; seabuckthorn ; Small intestine ; Superoxide dismutase ; Toxicity ; Vitamin C</subject><ispartof>Journal of food science, 2020-07, Vol.85 (7), p.2245-2254</ispartof><rights>2020 Institute of Food Technologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3493-f1ed9c659f3d60c78fe2599384c27714137c43b4b18f199a50a0a3f519e2d6493</citedby><cites>FETCH-LOGICAL-c3493-f1ed9c659f3d60c78fe2599384c27714137c43b4b18f199a50a0a3f519e2d6493</cites><orcidid>0000-0003-2325-9931</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1750-3841.15313$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1750-3841.15313$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Zhao, Sijia</creatorcontrib><creatorcontrib>Sun, Hongyang</creatorcontrib><creatorcontrib>Liu, Qingbo</creatorcontrib><creatorcontrib>Shen, Yu</creatorcontrib><creatorcontrib>Jiang, Yujun</creatorcontrib><creatorcontrib>Li, Yanhua</creatorcontrib><creatorcontrib>Liu, Tong</creatorcontrib><creatorcontrib>Liu, Tianxu</creatorcontrib><creatorcontrib>Xu, Honghua</creatorcontrib><creatorcontrib>Shao, Meili</creatorcontrib><title>Protective effect of seabuckthorn berry juice against acrylamide‐induced oxidative damage in rats</title><title>Journal of food science</title><description>Acrylamide (AA), classified as a probable carcinogen, can be neurotoxic, genotoxic, and can damage DNA. This study explored the ability of seabuckthorn berries juice (SBJ) to alleviate AA‐induced toxic injury in rats. Twenty‐four adult male Sprague‐Dawley (SD) rats were randomly divided into four groups: control group, AA group (40 mg/kg), AA + SBJ (40 mg/kg AA and 5 mL/kg SBJ), and AA + vitamin C (VC) group (positive control group, 40 mg/kg AA and 100 mg/kg VC). At the end of the experiment, rats in AA group showed a marked decrease in the rate of weight gain, hind extremity abduction, and ataxia. Obvious anomalies were seen in plasma biochemical parameters (P < 0.05), and different degrees of injury were observed upon histological examination of five tissues (hippocampus, cerebellum, liver, small intestine, and kidney). Compared to the control group, levels of superoxide dismutase, catalase, and glutathione were significantly decreased, while malondialdehyde was elevated (P < 0.05). SBJ treatment reduced the abnormal of behavior, hematological index, antioxidant enzyme, and tissue damage caused by AA in rats.
Practical Application
Seabuckthorn berries are wild berries rich in vitamin C and polyphenols, which have good antioxidant properties. In this experiment, SBJ has a significant alleviating effect on AA‐induced oxidative damage in rats. Therefore, we speculate that SBJ may relieve the oxidative damage caused by diet or other forms of AA exposure in the general population. At the same time, this experiment also provides new ideas for alleviating AA‐induced in vivo toxicity.</description><subject>Acrylamide</subject><subject>Anomalies</subject><subject>Antioxidants</subject><subject>Ascorbic acid</subject><subject>Ataxia</subject><subject>Berries</subject><subject>Biocompatibility</subject><subject>Body weight gain</subject><subject>Carcinogens</subject><subject>Catalase</subject><subject>Cerebellum</subject><subject>Damage</subject><subject>DNA damage</subject><subject>Experiments</subject><subject>Fruits</subject><subject>Genotoxicity</subject><subject>Glutathione</subject><subject>Hippophae</subject><subject>in vivo</subject><subject>Intestine</subject><subject>Kidneys</subject><subject>Malondialdehyde</subject><subject>Neurotoxicity</subject><subject>oxidative damage</subject><subject>Polyphenols</subject><subject>rats</subject><subject>seabuckthorn</subject><subject>Small intestine</subject><subject>Superoxide dismutase</subject><subject>Toxicity</subject><subject>Vitamin C</subject><issn>0022-1147</issn><issn>1750-3841</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFUMtOwzAQtBBIlMCZqyXOae3YSeojKpSHKoEEnC3HXheXNil2AuTGJ_CNfAlJg7iyWmkfmpnVDkKnlIxpFxOapyRmU07HNGWU7aHR32YfjQhJkphSnh-ioxBWpJ9ZNkL63lc16Nq9AQZruw5XFgdQRaNf6ufKl7gA71u8apwGrJbKlaHGSvt2rTbOwPfnlytNo8Hg6sMZtVMyaqOWgF2JvarDMTqwah3g5LdG6Gl--Ti7jhd3Vzez80WsGRcsthSM0FkqLDMZ0fnUQpIK0T2gkzynnLJcc1bwgk4tFUKlRBHFbEoFJCbrFCJ0NuhuffXaQKjlqmp82Z2UCU94xgjrMkKTAaV9FYIHK7febZRvJSWyd1L2vsneN7lzsmNkA-PdraH9Dy5v5xcPA_EH5bd2dQ</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Zhao, Sijia</creator><creator>Sun, Hongyang</creator><creator>Liu, Qingbo</creator><creator>Shen, Yu</creator><creator>Jiang, Yujun</creator><creator>Li, Yanhua</creator><creator>Liu, Tong</creator><creator>Liu, Tianxu</creator><creator>Xu, Honghua</creator><creator>Shao, Meili</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0003-2325-9931</orcidid></search><sort><creationdate>202007</creationdate><title>Protective effect of seabuckthorn berry juice against acrylamide‐induced oxidative damage in rats</title><author>Zhao, Sijia ; Sun, Hongyang ; Liu, Qingbo ; Shen, Yu ; Jiang, Yujun ; Li, Yanhua ; Liu, Tong ; Liu, Tianxu ; Xu, Honghua ; Shao, Meili</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3493-f1ed9c659f3d60c78fe2599384c27714137c43b4b18f199a50a0a3f519e2d6493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acrylamide</topic><topic>Anomalies</topic><topic>Antioxidants</topic><topic>Ascorbic acid</topic><topic>Ataxia</topic><topic>Berries</topic><topic>Biocompatibility</topic><topic>Body weight gain</topic><topic>Carcinogens</topic><topic>Catalase</topic><topic>Cerebellum</topic><topic>Damage</topic><topic>DNA damage</topic><topic>Experiments</topic><topic>Fruits</topic><topic>Genotoxicity</topic><topic>Glutathione</topic><topic>Hippophae</topic><topic>in vivo</topic><topic>Intestine</topic><topic>Kidneys</topic><topic>Malondialdehyde</topic><topic>Neurotoxicity</topic><topic>oxidative damage</topic><topic>Polyphenols</topic><topic>rats</topic><topic>seabuckthorn</topic><topic>Small intestine</topic><topic>Superoxide dismutase</topic><topic>Toxicity</topic><topic>Vitamin C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Sijia</creatorcontrib><creatorcontrib>Sun, Hongyang</creatorcontrib><creatorcontrib>Liu, Qingbo</creatorcontrib><creatorcontrib>Shen, Yu</creatorcontrib><creatorcontrib>Jiang, Yujun</creatorcontrib><creatorcontrib>Li, Yanhua</creatorcontrib><creatorcontrib>Liu, Tong</creatorcontrib><creatorcontrib>Liu, Tianxu</creatorcontrib><creatorcontrib>Xu, Honghua</creatorcontrib><creatorcontrib>Shao, Meili</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Journal of food science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Sijia</au><au>Sun, Hongyang</au><au>Liu, Qingbo</au><au>Shen, Yu</au><au>Jiang, Yujun</au><au>Li, Yanhua</au><au>Liu, Tong</au><au>Liu, Tianxu</au><au>Xu, Honghua</au><au>Shao, Meili</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of seabuckthorn berry juice against acrylamide‐induced oxidative damage in rats</atitle><jtitle>Journal of food science</jtitle><date>2020-07</date><risdate>2020</risdate><volume>85</volume><issue>7</issue><spage>2245</spage><epage>2254</epage><pages>2245-2254</pages><issn>0022-1147</issn><eissn>1750-3841</eissn><abstract>Acrylamide (AA), classified as a probable carcinogen, can be neurotoxic, genotoxic, and can damage DNA. This study explored the ability of seabuckthorn berries juice (SBJ) to alleviate AA‐induced toxic injury in rats. Twenty‐four adult male Sprague‐Dawley (SD) rats were randomly divided into four groups: control group, AA group (40 mg/kg), AA + SBJ (40 mg/kg AA and 5 mL/kg SBJ), and AA + vitamin C (VC) group (positive control group, 40 mg/kg AA and 100 mg/kg VC). At the end of the experiment, rats in AA group showed a marked decrease in the rate of weight gain, hind extremity abduction, and ataxia. Obvious anomalies were seen in plasma biochemical parameters (P < 0.05), and different degrees of injury were observed upon histological examination of five tissues (hippocampus, cerebellum, liver, small intestine, and kidney). Compared to the control group, levels of superoxide dismutase, catalase, and glutathione were significantly decreased, while malondialdehyde was elevated (P < 0.05). SBJ treatment reduced the abnormal of behavior, hematological index, antioxidant enzyme, and tissue damage caused by AA in rats.
Practical Application
Seabuckthorn berries are wild berries rich in vitamin C and polyphenols, which have good antioxidant properties. In this experiment, SBJ has a significant alleviating effect on AA‐induced oxidative damage in rats. Therefore, we speculate that SBJ may relieve the oxidative damage caused by diet or other forms of AA exposure in the general population. At the same time, this experiment also provides new ideas for alleviating AA‐induced in vivo toxicity.</abstract><cop>Chicago</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/1750-3841.15313</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2325-9931</orcidid></addata></record> |
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| subjects | Acrylamide Anomalies Antioxidants Ascorbic acid Ataxia Berries Biocompatibility Body weight gain Carcinogens Catalase Cerebellum Damage DNA damage Experiments Fruits Genotoxicity Glutathione Hippophae in vivo Intestine Kidneys Malondialdehyde Neurotoxicity oxidative damage Polyphenols rats seabuckthorn Small intestine Superoxide dismutase Toxicity Vitamin C |
| title | Protective effect of seabuckthorn berry juice against acrylamide‐induced oxidative damage in rats |
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