Protective effect of seabuckthorn berry juice against acrylamide‐induced oxidative damage in rats

Acrylamide (AA), classified as a probable carcinogen, can be neurotoxic, genotoxic, and can damage DNA. This study explored the ability of seabuckthorn berries juice (SBJ) to alleviate AA‐induced toxic injury in rats. Twenty‐four adult male Sprague‐Dawley (SD) rats were randomly divided into four gr...

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Veröffentlicht in:Journal of food science 2020-07, Vol.85 (7), p.2245-2254
Hauptverfasser: Zhao, Sijia, Sun, Hongyang, Liu, Qingbo, Shen, Yu, Jiang, Yujun, Li, Yanhua, Liu, Tong, Liu, Tianxu, Xu, Honghua, Shao, Meili
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Sprache:eng
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Zusammenfassung:Acrylamide (AA), classified as a probable carcinogen, can be neurotoxic, genotoxic, and can damage DNA. This study explored the ability of seabuckthorn berries juice (SBJ) to alleviate AA‐induced toxic injury in rats. Twenty‐four adult male Sprague‐Dawley (SD) rats were randomly divided into four groups: control group, AA group (40 mg/kg), AA + SBJ (40 mg/kg AA and 5 mL/kg SBJ), and AA + vitamin C (VC) group (positive control group, 40 mg/kg AA and 100 mg/kg VC). At the end of the experiment, rats in AA group showed a marked decrease in the rate of weight gain, hind extremity abduction, and ataxia. Obvious anomalies were seen in plasma biochemical parameters (P
ISSN:0022-1147
1750-3841
DOI:10.1111/1750-3841.15313