Photodynamic treatment of melanoma cells using aza-dipyrromethenes as photosensitizers

In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT. The synthesis and characterization of the ADPMs and their photodynamic action against B16F10 melanoma cells were assessed. ADPM 2 is the best singlet oxygen generator and the m...

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Veröffentlicht in:	Photochemical & photobiological sciences 2020-07, Vol.19 (7), p.885-891
Hauptverfasser:	Castro, Kelly A. D. F, Costa, Letícia D, Guieu, Samuel, Biazzotto, Juliana C, Neves, Maria da Graça P. M. S, Faustino, M. Amparo F, da Silva, Roberto, Tomé, Augusto C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Aza Compounds - chemical synthesis Aza Compounds - chemistry Aza Compounds - pharmacology Biochemistry Biomaterials Cell Proliferation - drug effects Cell Survival - drug effects Chemistry Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Melanoma Melanoma - drug therapy Melanoma - pathology Mice Molecular Structure Photochemotherapy Photosensitizing Agents - chemical synthesis Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Physical Chemistry Plant Sciences Porphobilinogen - analogs & derivatives Porphobilinogen - chemical synthesis Porphobilinogen - chemistry Porphobilinogen - pharmacology Singlet oxygen Structure-Activity Relationship Tumor Cells, Cultured
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Zusammenfassung:	In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT. The synthesis and characterization of the ADPMs and their photodynamic action against B16F10 melanoma cells were assessed. ADPM 2 is the best singlet oxygen generator and the most phototoxic (at 2.5 μM) towards B16F10 cells. In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT.
ISSN:	1474-905X 1474-9092
DOI:	10.1039/d0pp00114g