Nonenzymatic amperometric sensor for hydrogen peroxide released from living cancer cells based on hierarchical NiCo2O4-CoNiO2 hybrids embedded in partially reduced graphene oxide
The synthesis of hierarchical NiCo 2 O 4 -CoNiO 2 hybrids embedded in partially reduced graphene oxide (represented by NiCo 2 O 4 /CoNiO 2 @pPRGO) is described. They were derived from ultrathin CoNi-based zeolitic imidazolate framework (CoNi-ZIF) nanosheets vertically grew on three-dimensional (3D)...
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Veröffentlicht in: | Mikrochimica acta (1966) 2020-08, Vol.187 (8), Article 436 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The synthesis of hierarchical NiCo
2
O
4
-CoNiO
2
hybrids embedded in partially reduced graphene oxide (represented by NiCo
2
O
4
/CoNiO
2
@pPRGO) is described. They were derived from ultrathin CoNi-based zeolitic imidazolate framework (CoNi-ZIF) nanosheets vertically grew on three-dimensional (3D) pRGO networks by pyrolysis at different temperatures (300, 600, and 900 °C) in N
2
atmosphere. Transmission electron microscopy, X-ray diffraction, and X-ray photoemission spectroscopy measurements showed that the metal coordination centers (Co or Ni) were transferred into NiCo
2
O
4
spinel and CoNiO
2
nanostructures, along with a small number of metallic states of Co and Ni. In view of good electrochemical conductivity and large specific surface area of pRGO, good catalytic activity of Co- and Ni-contained NPs, and homogeneous distribution of NPs within the pRGO network, the NiCo
2
O
4
/CoNiO
2
@pRGO
600
nanohybrid calcined at 600 °C displayed superior electrocatalytic activity toward hydrogen peroxide (H
2
O
2
) reduction. A glassy carbon electrode modified with NiCo
2
O
4
/CoNiO
2
@pRGO
600
was used for determination of H
2
O
2
by amperometry at an applied potential of − 0.4 V vs. Ag/AgCl. The nonenzymatic amperometric sensor exhibited high sensitivity and low detection limit (0.41 μM) within a wide working range (5 μM–3 mM and 3–12 mM) toward H
2
O
2
, as well as good selectivity, reproducibility, and long-term stability. Benefiting from the good biocompatibility and remarkable analytical performances of NiCo
2
O
4
/CoNiO
2
@pRGO
600
, the assay was used to determine real-time H
2
O
2
released from living cancer cells.
Graphical abstract |
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ISSN: | 0026-3672 1436-5073 |
DOI: | 10.1007/s00604-020-04419-z |