GI highlights from the literature

Furthermore, oral administration of the human commensal bacterium, Lactobacillus rhamnosus GG (LGG), to conventional mice resulted in potent hepatic Nrf2 activation and this was sufficient to protect against acute oxidative liver injury in two separate mouse models (paracetamol overdose and acute ethanol toxicity). Despite approximately 1000-fold higher gene expression of ACE2 on differentiated relative to progenitor enterocytes, similar infection rates of both cell types were observed suggesting viral entry may be facilitated by even low levels of the receptor. [...]Lgr5 (Leucine-rich repeat-containing G protein-coupled receptor 5) a well-defined intestinal stem cell marker has been shown to be an antral stem cell marker. On multivariable regression analysis, weight loss was the only independent factor associated with reduction in liver fat.