193-LB: Diabetes Mellitus Does Not Impact Negatively on Outcomes of Hospitalizations Primarily for Systemic Lupus Erythematosus (SLE): An Analysis of the National Inpatient Sample Database

Background: Diabetes mellitus (DM) is a multisystemic disorder, known to be associated with worse outcomes of multiple conditions. Objectives: This study aims to determine if diabetes has an impact on outcomes of hospitalizations primarily for SLE. Methods: Data were extracted from the Nationwide Inpatient Sample (NIS) 2016 and 2017 database. The NIS was searched for SLE as the principal diagnosis for hospitalizations in 2016 and 2017, with and without DM as a secondary diagnosis, using ICD-10 codes. Adult Patients from the above groups were included. The primary outcome was inpatient mortality, while secondary outcomes were length of stay (LOS) and Total hospital charge. Multivariate logistic and linear regression analysis were used to adjust for possible confounders for the primary and secondary outcomes respectively. Results: 20630 hospitalizations were for adult patients, who had principal diagnosis of SLE. 18560 (90.0%) of these hospitalizations had no secondary diagnosis of DM and 2070 (10.0%) had a secondary diagnosis of DM. A total of 255 inpatient mortality (1.23%) occurred in SLE hospitalizations, 35 (1.19%) of which occurred in patients with DM. The adjusted odds ratio (AOR) of inpatient mortality for SLE with DM compared to without DM was 0.554 (95% CI: 0.233 - 1.315, P=0.180). Hospitalizations with SLE and DM had a decreased adjusted mean LOS of 2.1 days (95% CI -3.0 - {-1.1}, P=0.000) compared to without DM. The adjusted mean total hospital charge for SLE and DM hospitalizations was also decreased by $24875 compared to without DM (95% CI -36154 - {-13596}, P=0.000). Conclusions: There was no statistically significant difference in inpatient mortality of hospitalizations for SLE with DM compared to SLE without DM. Interestingly, SLE with DM hospitalizations has a shorter LOS and lower total hospital charge compared to without DM.