2154-PUB: Determination of Non-HDL Cholesterol in Type 1 Diabetic Patients

Aim: To describe non-HDL cholesterol levels (non-HDL-c) and the factors that might interfere with these levels in children with type 1 diabetes (T1D), determining their cost-effectiveness compared to LDL-cholesterol (LDL-c) in clinical practice and the laboratory cut-off point suggestion for intervention. Method: Cross-sectional descriptive study with analysis of cholesterol levels, especially non-HDL-c, in children (under 19 years old) with T1D and in a control group (children under 19 years without diabetes).Were evaluated 144 T1D and 138 controls. The variables were anthropometric data, pubertal staging, glycated hemoglobin (A1c) and lipid profile. Patients with disease or on medications that could cause dyslipidemia were exclude from this study. The variables were analyze using RedCap and Jamovi. Results: A total of 282 children participated in this study. The non-HDL-c was 122.64 ± 37.67 and in the control was 108.70 ± 28.10, with no significant difference between them. Non-HDL-c was significantly correlated with A1c (p= 0,001), but did not correlate with gender, BMI, disease duration and pubertal stage. There was observed that LDL-c and had a strong correlation with each other R = 0.929. According to LDL-c abnormality values proposed for children (where values between 100 and 130 mg/dl, should initiate lifestyle change and above 130 mg/dl, drug therapy) the ROC curve presented a cutoff value of non-HDL-c of 125mg ∕ dl and 147mg ∕ dl. Conclusion: In this population, glycemic control seems to interfere with the lipid profile, which wasn’t observed with BMI and index and pubertal stage. This study also suggest a lower cut-off point of non-HDL-c for therapeutic intervention.