557-P: Gastric Electrical Neurostimulation Combined with Pyloroplasty for Refractory Diabetic Gastroparesis Improves Subjective and Objective Outcomes

557-P: Gastric Electrical Neurostimulation Combined with Pyloroplasty for Refractory Diabetic Gastroparesis Improves Subjective and Objective Outcomes

Background: Gastric electrical stimulation (GES) improves symptoms in diabetic gastroparesis (DM GP) refractory to medical therapies but does not increase gastric emptying (GE). This study investigates the clinical outcomes of GES combined with pyloroplasty (PP) to improve GE as well as the pathophy...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2020-06, Vol.69 (Supplement_1)
Hauptverfasser: BRIGHT, TAMIS, SAROSIEK, IRENE, SHANKER, AARON, DAVIS, BRIAN R., PADILLA, OSVALDO, DIAZ, JESUS R., ESPINO, KARINA, MCCALLUM, RICHARD M.
Format: Artikel
Sprache:eng
Schlagworte:
Diabetes
Diabetes mellitus
Electrical stimuli
Gastric emptying
Interstitial cells
Interstitial cells of Cajal
Nausea
Patients
Satiety
Scintigraphy
Surgery
Vomiting
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Zusammenfassung:Background: Gastric electrical stimulation (GES) improves symptoms in diabetic gastroparesis (DM GP) refractory to medical therapies but does not increase gastric emptying (GE). This study investigates the clinical outcomes of GES combined with pyloroplasty (PP) to improve GE as well as the pathophysiological characteristics of the responding patients. Methods: Overall 39 DM (13 type I) GP patients with 16.6 (range 3-50) years of DM had GES with PP. Antral and pyloric biopsies were assessed for interstitial cells of Cajal (ICC) status. Depletion of ICC was defined as
ISSN:0012-1797
1939-327X
DOI:10.2337/db20-557-P