1807-P: MR-Based Assessments Better Capture Pathophysiologic Profiles in Nonalcoholic Fatty Liver Disease

Aims/Introduction: Several non-invasive tools are available for the assessment of steatosis and fibrosis in nonalcoholic fatty liver disease (NAFLD) including clinical scoring systems, serum markers, transient elastography (TE), and magnetic resonance imaging (MRI) techniques, such as MRI-proton density fat fraction (MRI-PDFF) and MR elastography (MRE). In the present study, we aimed to evaluate whether MRI-based examinations better reflected the pathophysiology and metabolic features of NAFLD and outperformed other non-invasive methods. Materials and Methods: A total of 120 subjects (31 healthy volunteers and 89 NAFLD patients) were subjected to anthropometric and laboratory tests, TE, and MRI-based examinations in this cross-sectional study, including liver biopsy in some patients (n=39). Results: MRI-PDFF correlated with hepatic fat measured by MR spectroscopy (r=0.978, p